@import url('https://fonts.googleapis.com/css2?family=Inter:wght@300;400;500;600;700&display=swap');
  @font-face {
    font-family: 'Gotham';
    src: url('Gotham/Gotham-Bold.otf') format('opentype');
    font-weight: 700;
    font-style: normal;
  }

  :root {
    --blue: #1a56db;
    --blue-dark: #1e40af;
    --blue-light: #eff6ff;
    --blue-mid: #3b82f6;
    --bg: #ffffff;
    --surface: #f8fafc;
    --border: #e2e8f0;
    --muted: #64748b;
    --text: #0f172a;
    --text-soft: #334155;
    --green: #059669;
    --green-bg: #f0fdf4;
    --green-border: #6ee7b7;
    --amber: #d97706;
    --amber-bg: #fffbeb;
    --amber-border: #fcd34d;
  }

  * { box-sizing: border-box; margin: 0; padding: 0; }
  body { font-family: 'Inter', system-ui, sans-serif; background: var(--bg); color: var(--text); font-size: 16px; line-height: 1.75; -webkit-font-smoothing: antialiased; }

  /* ── Header: blue brand bar + white topic row ──────────────────── */
    header { border-radius: 16px; overflow: hidden; margin-bottom: 0; }
    .header-brand { background: var(--blue); padding: 32px 0; text-align: center; }
    .header-brand-inner { display: flex; align-items: center; justify-content: center; gap: 18px; }
    .header-logo { width: 56px; height: 56px; border-radius: 50%; background: rgba(255,255,255,0.18); flex-shrink: 0; display: flex; align-items: center; justify-content: center; overflow: hidden; }
    .header-logo img { width: 52px; height: 52px; object-fit: contain; }
    .header-brand-name { font-family: 'Gotham', 'Arial Black', sans-serif; font-size: 1.8rem; font-weight: 800; color: #fff; letter-spacing: 0.04em; text-transform: uppercase; }
    .header-topic { background: #fff; border: 1px solid var(--border); border-top: none; border-radius: 0 0 16px 16px; padding: 24px 0 20px; text-align: center; }
    header h1 { font-family: 'Gotham', 'Arial Black', sans-serif; font-weight: 700; font-size: 2rem; letter-spacing: 0.02em; line-height: 1.1; color: var(--text); margin-bottom: 8px; }
    .header-sub { font-size: 13px; color: var(--muted); line-height: 1.5; }
    .header-label { display: none; }

  /* ── Briefing header: blue-strip design (active when .has-mmb-nav) ─ */
    body.has-mmb-nav header { border-radius: 0; overflow: visible; }
    body.has-mmb-nav .header-brand { display: none; }
    body.has-mmb-nav .header-topic { background: var(--blue); border: none; border-radius: 0; padding: 44px 0 40px; }
    body.has-mmb-nav header h1 { color: #fff; }
    body.has-mmb-nav .header-sub { color: rgba(255,255,255,0.72); }
    body.has-mmb-nav .header-label { display: block; font-size: 0.72rem; font-weight: 600; letter-spacing: 0.1em; text-transform: uppercase; color: rgba(255,255,255,0.6); margin-bottom: 8px; }

  /* ── Global Navbar ───────────────────────────────────────────────── */
    .mmb-nav { background: #fff; border-bottom: 1px solid var(--border); position: sticky; top: 0; z-index: 200; }
    .mmb-nav-inner { max-width: 1200px; margin: 0 auto; padding: 0 28px; display: flex; align-items: center; justify-content: space-between; height: 58px; }
    .mmb-nav-brand { display: flex; align-items: center; gap: 10px; text-decoration: none; flex-shrink: 0; }
    .mmb-nav-logo-img { height: 32px; width: auto; object-fit: contain; display: block; }
    .mmb-nav-links { display: flex; align-items: center; gap: 2px; list-style: none; margin: 0; padding: 0; }
    .mmb-nav-links a { padding: 6px 12px; font-size: 13px; font-weight: 500; color: var(--text-soft); text-decoration: none; border-radius: 6px; white-space: nowrap; }
    .mmb-nav-links a:hover { background: var(--surface); color: var(--text); }
    .mmb-nav-links .nav-sub { background: var(--text); color: #fff !important; font-weight: 600; border-radius: 8px; padding: 7px 16px; margin-left: 8px; }
    .mmb-nav-links .nav-sub:hover { background: #1e293b !important; color: #fff; }
    /* Hamburger button (hidden on desktop) */
    .mmb-nav-hamburger { display: none; background: none; border: none; cursor: pointer; padding: 6px; color: var(--text); line-height: 0; }
    .mmb-nav-mobile-sub { display: none; }
    /* Mobile dropdown (hidden by default) */
    .mmb-nav-dropdown { display: none; position: fixed; top: 58px; left: 0; right: 0; background: #fff; border-bottom: 1px solid var(--border); box-shadow: 0 4px 16px rgba(0,0,0,0.1); z-index: 199; }
    .mmb-nav-dropdown.open { display: block; }
    .mmb-nav-dropdown a { display: block; padding: 15px 20px; font-size: 15px; font-weight: 500; color: var(--text-soft); text-decoration: none; border-bottom: 1px solid var(--border); }
    .mmb-nav-dropdown a:last-child { border-bottom: none; }
    .mmb-nav-dropdown a:hover { color: var(--blue); background: var(--surface); }
    .mmb-nav-dropdown .mmb-nav-dd-sub { color: #fff; background: var(--text); font-weight: 700; }
    .mmb-nav-dropdown .mmb-nav-dd-sub:hover { background: var(--blue); color: #fff; }

  /* ── Share Strip (matches Medical News style) ───────────────────── */
    .share-strip { display: flex; align-items: center; gap: 6px; padding: 16px 0 0; margin: 24px 0; border-top: 1px solid var(--border); }
    .share-strip-label { font-size: 10.5px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.1em; color: var(--muted); margin-right: 6px; flex-shrink: 0; }
    .share-strip-btn { display: flex; align-items: center; justify-content: center; width: 34px; height: 34px; border: 1.5px solid #e2e8f0; border-radius: 7px; color: #475569; text-decoration: none; background: white; cursor: pointer; font-family: inherit; flex-shrink: 0; transition: border-color .15s, color .15s, background .15s; }
    .share-strip-btn:hover { border-color: #94a3b8; color: #0f172a; background: #f8fafc; }
    .share-strip-div { width: 1px; height: 18px; background: var(--border); margin: 0 2px; flex-shrink: 0; }

  .container { max-width: 760px; margin: 0 auto; padding: 0 24px; }
  .big-picture { background: var(--blue-light); border: 1px solid #bfdbfe; border-left: 4px solid var(--blue); border-radius: 8px; padding: 28px 32px; margin: 36px 0 32px; }
  .bp-label { font-size: 10px; font-weight: 700; letter-spacing: 0.18em; text-transform: uppercase; color: var(--blue); margin-bottom: 10px; }
  .big-picture p { font-size: 0.9rem; line-height: 1.8; color: var(--text-soft); }
  .stats-row { display: grid; grid-template-columns: repeat(3, 1fr); margin: 28px 0; border: 1px solid var(--border); border-radius: 10px; overflow: hidden; }
  .stat-pill { padding: 18px 16px; border-right: 1px solid var(--border); border-bottom: 1px solid var(--border); display: flex; flex-direction: column; font-size: 0.72rem; color: #94a3b8; line-height: 1.4; }
  .stat-pill:nth-child(3n) { border-right: none; }
  .stat-pill span { font-size: 1.5rem; font-weight: 800; color: var(--blue); line-height: 1.1; display: block; margin-bottom: 5px; }
  h2 { font-size: 15px; font-weight: 800; letter-spacing: 0.06em; text-transform: uppercase; color: var(--blue); margin: 44px 0 14px; padding-bottom: 8px; border-bottom: 2px solid var(--blue-light); }
  p { margin-bottom: 14px; color: var(--text-soft); }
  p:last-child { margin-bottom: 0; }
  strong { color: var(--text); font-weight: 600; }

  .alert-box { background: var(--blue-light); border: 1px solid #bfdbfe; border-left: 4px solid var(--blue); border-radius: 8px; padding: 18px 22px; margin: 22px 0; font-size: 0.94rem; }
  .alert-box.amber { background: var(--amber-bg); border-color: var(--amber-border); border-left-color: var(--amber); }
  .alert-box.green { background: var(--green-bg); border-color: var(--green-border); border-left-color: var(--green); }
  .alert-label { font-size: 10px; font-weight: 700; letter-spacing: 0.14em; text-transform: uppercase; color: var(--blue); margin-bottom: 6px; }
  .alert-box.amber .alert-label { color: var(--amber); }
  .alert-box.green .alert-label { color: var(--green); }

  .pocus-box { background: var(--green-bg); border: 1px solid var(--green-border); border-left: 4px solid var(--green); border-radius: 8px; padding: 22px 26px; margin: 26px 0; }
  .pocus-label { font-size: 10px; font-weight: 700; letter-spacing: 0.14em; text-transform: uppercase; color: var(--green); margin-bottom: 10px; }
  .pocus-box p { font-size: 0.94rem; }

  .tx-table { width: 100%; border-collapse: collapse; font-size: 0.87rem; margin: 18px 0; background: var(--bg); border: 1px solid var(--border); border-radius: 8px; overflow: hidden; }
  .tx-table thead { background: var(--blue); color: #fff; }
  .tx-table thead th { font-size: 10px; font-weight: 600; letter-spacing: 0.08em; text-transform: uppercase; padding: 9px 12px; text-align: left; }
  .tx-table tbody tr:nth-child(even) { background: var(--surface); }
  .tx-table tbody td { padding: 9px 12px; border-bottom: 1px solid var(--border); color: var(--text-soft); vertical-align: top; line-height: 1.5; }

  .sev-table { width: 100%; border-collapse: collapse; font-size: 0.87rem; margin: 18px 0; background: var(--bg); border: 1px solid var(--border); border-radius: 8px; overflow: hidden; }
  .sev-table thead { background: var(--blue); color: #fff; }
  .sev-table thead th { font-size: 10px; font-weight: 600; letter-spacing: 0.08em; text-transform: uppercase; padding: 9px 12px; text-align: left; }
  .sev-table tbody tr:nth-child(even) { background: var(--surface); }
  .sev-table tbody td { padding: 8px 12px; border-bottom: 1px solid var(--border); color: var(--text-soft); vertical-align: top; }

  .guideline-box { background: var(--bg); border: 1px solid var(--border); border-radius: 8px; overflow: hidden; margin: 22px 0; }
  .guideline-box h3 { background: var(--blue); color: #fff; padding: 10px 14px; font-size: 0.88rem; font-weight: 700; margin: 0; letter-spacing: 0; text-transform: none; border-bottom: 1px solid rgba(255,255,255,0.2); }
  .guideline-box table { width: 100%; border-collapse: collapse; font-size: 0.88rem; }
  .guideline-box thead { background: var(--blue); color: #fff; }
  .guideline-box thead th { font-size: 10px; font-weight: 600; letter-spacing: 0.1em; text-transform: uppercase; padding: 10px 14px; text-align: left; }
  .guideline-box tbody tr:nth-child(even) { background: var(--surface); }
  .guideline-box tbody td { padding: 10px 14px; border-bottom: 1px solid var(--border); vertical-align: top; line-height: 1.5; color: var(--text-soft); }
  .badge { display: inline-block; font-size: 10px; font-weight: 700; padding: 2px 7px; border-radius: 4px; letter-spacing: 0.05em; }
  .badge-i { background: #dbeafe; color: #1e40af; }
  .badge-iia { background: #d1fae5; color: #065f46; }
  .badge-iib { background: #fef3c7; color: #92400e; }
  .badge-iii { background: #fee2e2; color: #991b1b; }

  .fellow-pearl { background: #f5f3ff; border: 1px solid #ddd6fe; border-left: 4px solid #7c3aed; border-radius: 8px; padding: 20px 24px; margin: 22px 0; }
  .fellow-label { font-size: 10px; font-weight: 700; letter-spacing: 0.14em; text-transform: uppercase; color: #7c3aed; margin-bottom: 8px; }
  .cite { color: var(--blue); font-weight: 600; cursor: default; }
  .guideline-box h3 .cite { color: rgba(255,255,255,0.75); }

  .lm-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 12px; margin: 18px 0; }
  .lm-card { background: var(--surface); border: 1px solid var(--border); border-radius: 8px; padding: 14px 16px; font-size: 0.86rem; line-height: 1.5; }
  .lm-card a { color: var(--blue); text-decoration: none; font-weight: 600; }
  .lm-card a:hover { text-decoration: underline; }
  .lm-tag { font-size: 9px; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; color: var(--muted); margin-bottom: 4px; }
  .lm-card p { font-size: 0.82rem; color: var(--muted); margin-top: 5px; }

  /* ── Hemodynamic Profile Grid ────────────────────────────── */
  .hemo-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 14px; margin: 24px 0; }
  .hemo-card { border-radius: 10px; padding: 18px 20px; border: 1px solid var(--border); background: var(--surface); }
  .hemo-card-title { font-size: 11px; font-weight: 700; letter-spacing: 0.1em; text-transform: uppercase; margin-bottom: 10px; color: var(--text); }
  .hemo-label { font-size: 12px; font-weight: 700; text-transform: uppercase; letter-spacing: 0.06em; margin-bottom: 10px; }
  .hemo-params > div { display: grid; grid-template-columns: 105px 1fr; gap: 8px; padding: 5px 0; font-size: 0.86rem; line-height: 1.4; border-bottom: 1px solid var(--border); }
  .hemo-params > div:last-child { border-bottom: none; }
  .hemo-params > div > span { font-weight: 600; color: var(--text); font-size: 0.82rem; }
  .hemo-card.warm-wet { background: linear-gradient(135deg,#fff5f5 0%,#ffe4e6 100%); border-color: #fca5a5; border-left: 4px solid #ef4444; }
  .hemo-card.warm-wet .hemo-card-title { color: #b91c1c; }
  .hemo-card.cold-wet { background: linear-gradient(135deg,#eff6ff 0%,#dbeafe 100%); border-color: #93c5fd; border-left: 4px solid #3b82f6; }
  .hemo-card.cold-wet .hemo-card-title { color: #1d4ed8; }
  .hemo-card.warm-dry { background: linear-gradient(135deg,#fffbeb 0%,#fef3c7 100%); border-color: #fcd34d; border-left: 4px solid #f59e0b; }
  .hemo-card.warm-dry .hemo-card-title { color: #92400e; }
  .hemo-card.cold-dry { background: linear-gradient(135deg,#f8fafc 0%,#f1f5f9 100%); border-color: #cbd5e1; border-left: 4px solid #64748b; }
  .hemo-card.cold-dry .hemo-card-title { color: #334155; }
  .hemo-card.purple-vol { background: linear-gradient(135deg,#f5f3ff 0%,#ede9fe 100%); border-color: #c4b5fd; border-left: 4px solid #7c3aed; }
  .hemo-card.purple-vol .hemo-card-title { color: #7c3aed; }
  .hemo-card.amber-rheum { background: linear-gradient(135deg,#fef3c7 0%,#fde68a 50%); border-color: #f59e0b; border-left: 4px solid #d97706; }
  .hemo-card.amber-rheum .hemo-card-title { color: #92400e; }

  .references { margin: 44px 0 60px; border-top: 1px solid var(--border); padding-top: 24px; }
  .references h2 { margin-top: 0; }
  .ref-list { font-size: 0.8rem; line-height: 1.65; color: var(--muted); }
  .ref-list p { margin-bottom: 7px; padding-left: 26px; text-indent: -26px; }
  .ref-list a { color: var(--blue); text-decoration: none; }

  .media-section { margin: 44px 0; }
  .media-grid-cards { display: grid; grid-template-columns: 1fr 1fr; gap: 14px; margin: 18px 0; }
  .media-card { background: var(--surface); border: 1px solid var(--border); border-radius: 10px; overflow: hidden; transition: box-shadow .2s; }
  .media-card:hover { box-shadow: 0 4px 16px rgba(0,0,0,.08); }
  .media-thumb-link { display: block; }
  .media-thumb { width: 100%; aspect-ratio: 16/9; object-fit: cover; display: block; background: #e2e8f0; }
  .media-thumb-pod { width: 100%; aspect-ratio: 16/9; display: flex; flex-direction: column; align-items: center; justify-content: center; gap: 8px; padding: 12px; }
  .pod-icon { font-size: 1.8rem; }
  .pod-name { font-size: 0.78rem; font-weight: 700; color: rgba(255,255,255,0.92); text-align: center; letter-spacing: 0.03em; line-height: 1.3; }
  .media-body { padding: 12px 14px 14px; }
  .media-src-tag { font-size: 9px; font-weight: 700; letter-spacing: 0.12em; text-transform: uppercase; margin-bottom: 5px; display: inline-block; padding: 2px 7px; border-radius: 3px; }
  .media-src-tag.yt  { background: #fef2f2; color: #dc2626; }
  .media-src-tag.pod { background: #f0fdf4; color: #166534; }
  .media-title-card { font-size: 0.85rem; font-weight: 600; color: var(--text); line-height: 1.4; margin-bottom: 6px; }
  .media-desc-card { font-size: 0.77rem; color: var(--muted); line-height: 1.5; margin-bottom: 10px; }
  .media-btn { display: inline-block; font-size: 0.78rem; font-weight: 600; padding: 5px 14px; border-radius: 5px; text-decoration: none; transition: opacity .15s; }
  .media-btn:hover { opacity: 0.85; }
  .media-btn.watch  { background: var(--blue); color: #fff; }
  .media-btn.listen { background: #059669; color: #fff; }

  ol { padding-left: 22px; margin-bottom: 14px; color: var(--text-soft); }
  ol li { margin-bottom: 8px; padding-left: 4px; line-height: 1.65; }

  .class-table { width: 100%; border-collapse: collapse; font-size: 0.87rem; margin: 18px 0; background: var(--bg); border: 1px solid var(--border); border-radius: 8px; overflow: hidden; }
  .class-table thead { background: var(--blue); color: #fff; }
  .class-table thead th { font-size: 10px; font-weight: 600; letter-spacing: 0.08em; text-transform: uppercase; padding: 9px 12px; text-align: left; }
  .class-table tbody tr:nth-child(even) { background: var(--surface); }
  .class-table tbody td { padding: 9px 12px; border-bottom: 1px solid var(--border); color: var(--text-soft); vertical-align: top; line-height: 1.5; }

  /* ── Inline Case Report Callout ─────────────────────────── */
  .cr-inline-callout { border-top: 1px solid #e2e8f0; border-bottom: 1px solid #e2e8f0; padding: 0.85rem 0; margin: 1.5rem 0; }
  .cr-inline-callout-label { font-size: 0.68rem; font-weight: 700; text-transform: uppercase; letter-spacing: 0.14em; color: #dc2626; margin-bottom: 0.3rem; }
  .cr-inline-callout a { font-size: 1rem; font-weight: 700; color: #1e293b; text-decoration: underline; text-decoration-color: #cbd5e1; display: block; line-height: 1.35; }
  .cr-inline-callout a:hover { text-decoration-color: #2563eb; color: #2563eb; }

  /* ── Mobile — 600 px and below ──────────────────────────── */
  @media (max-width: 600px) {

    /* Base */
    body { font-size: 17px; line-height: 1.85; }
    p { font-size: 17px; }
    .container { padding: 0 14px; }

    /* Header — shrink brand bar for small screens */
    header { border-radius: 10px; }
    .header-brand { padding: 16px 0; }
    .header-brand-inner { gap: 10px; }
    .header-brand-name { font-size: 1.3rem; letter-spacing: 0.03em; }
    .header-logo { width: 40px; height: 40px; }
    .header-logo img { width: 36px; height: 36px; }
    .header-topic { padding: 16px 0 14px; }
    header h1 { font-size: 1.5rem; line-height: 1.2; }
    .header-label { font-size: 11px; }
    .header-sub { font-size: 13px; }
    /* Navbar — mobile: hide nav links, show hamburger (left) + subscribe (right) */
    .mmb-nav-links { display: none; }
    .mmb-nav-inner { height: 50px; padding: 0 12px; }
    .mmb-nav-hamburger { display: flex; order: -1; margin-right: 8px; }
    .mmb-nav-brand { flex: 1; }
    .mmb-nav-mobile-sub { display: flex; align-items: center; padding: 6px 12px; font-size: 12px; font-weight: 700; color: #fff; background: var(--text); border-radius: 7px; text-decoration: none; white-space: nowrap; flex-shrink: 0; }
    .mmb-nav-dropdown { display: none; }
    .mmb-nav-dropdown.open { display: block; }
    /* Blue-strip header — mobile */
    body.has-mmb-nav .header-topic { padding: 28px 0 24px; }
    /* Share strip — mobile */
    .share-strip { padding: 12px 0 0; }

    /* Big picture */
    .big-picture { padding: 16px 14px; }
    .big-picture p { font-size: 17px; }
    .bp-label { font-size: 10px; }

    /* Stat pills — 2 columns on mobile */
    .stats-row { grid-template-columns: repeat(2, 1fr); }
    .stat-pill { font-size: 11px; padding: 12px 10px; width: auto; }
    .stat-pill:nth-child(2n) { border-right: none; }
    .stat-pill:nth-child(3n) { border-right: 1px solid var(--border); }
    .stat-pill:nth-child(6n) { border-right: none; }
    .stat-pill span { font-size: 1.3rem; }

    /* h2 section headers */
    h2 { font-size: 13px; margin: 36px 0 12px; }

    /* Callout boxes */
    .alert-box, .pocus-box, .fellow-pearl { padding: 14px 14px; }
    .alert-label, .pocus-label, .fellow-label { font-size: 10px; }

    /* Tables — horizontal scroll */
    .sev-table, .tx-table, .class-table {
      display: block; overflow-x: auto; -webkit-overflow-scrolling: touch;
    }
    .guideline-box { overflow-x: auto; }
    .guideline-box table { font-size: 0.80rem; }
    .guideline-box thead th,
    .guideline-box tbody td { padding: 8px 10px; }

    /* Grids — single column */
    .hemo-grid { grid-template-columns: 1fr; gap: 10px; }
    .lm-grid { grid-template-columns: 1fr; }
    .media-grid-cards { grid-template-columns: 1fr; }

    /* Tags / labels */
    .lm-tag, .media-src-tag, .badge { font-size: 10px; }

    /* Media buttons — larger tap target */
    .media-btn { padding: 8px 16px; min-height: 40px; }

    /* References */
    .ref-list { font-size: 0.78rem; }
    .ref-list p { padding-left: 20px; text-indent: -20px; }

    /* ── Case report styles (shared so all 145 case pages benefit) ── */
    .cr-back-link { min-height: 44px; display: inline-flex; align-items: center; }
    .cr-section p { font-size: 0.95rem; line-height: 1.7; }
    .cr-labs { padding: 0.6rem 0.85rem; }
    .cr-lab-row { flex-direction: column; gap: 2px; }
    .cr-lab-name { min-width: auto; }
    .cr-fig img { max-height: 260px; }
    .cr-fig-caption { padding: 0.6rem 0.85rem; }
    .cr-takeaways { padding: 0.9rem 1rem; }
    .cr-meta-block { padding: 0.75rem 1rem; }
    .cr-links { flex-direction: column; gap: 0.5rem; }
    .cr-links a { min-height: 36px; display: inline-flex; align-items: center; }
    .cr-timeline { padding-left: 0.75rem; }
  }